Búsqueda | Biblioteca Virtual en Salud

1.

Atlas of the aging mouse brain reveals white matter as vulnerable foci.

Hahn, Oliver; Foltz, Aulden G; Atkins, Micaiah; Kedir, Blen; Moran-Losada, Patricia; Guldner, Ian H; Munson, Christy; Kern, Fabian; Pálovics, Róbert; Lu, Nannan; Zhang, Hui; Kaur, Achint; Hull, Jacob; Huguenard, John R; Grönke, Sebastian; Lehallier, Benoit; Partridge, Linda; Keller, Andreas; Wyss-Coray, Tony.

Cell ; 186(19): 4117-4133.e22, 2023 09 14.

Artículo Inglés | MEDLINE | ID: mdl-37591239

2.

Cerebrospinal fluid immune dysregulation during healthy brain aging and cognitive impairment.

Piehl, Natalie; van Olst, Lynn; Ramakrishnan, Abhirami; Teregulova, Victoria; Simonton, Brooke; Zhang, Ziyang; Tapp, Emma; Channappa, Divya; Oh, Hamilton; Losada, Patricia M; Rutledge, Jarod; Trelle, Alexandra N; Mormino, Elizabeth C; Elahi, Fanny; Galasko, Douglas R; Henderson, Victor W; Wagner, Anthony D; Wyss-Coray, Tony; Gate, David.

Cell ; 185(26): 5028-5039.e13, 2022 12 22.

Artículo Inglés | MEDLINE | ID: mdl-36516855

3.

Genetic variants of phospholipase C-Î³2 alter the phenotype and function of microglia and confer differential risk for Alzheimer's disease.

Tsai, Andy P; Dong, Chuanpeng; Lin, Peter Bor-Chian; Oblak, Adrian L; Viana Di Prisco, Gonzalo; Wang, Nian; Hajicek, Nicole; Carr, Adam J; Lendy, Emma K; Hahn, Oliver; Atkins, Micaiah; Foltz, Aulden G; Patel, Jheel; Xu, Guixiang; Moutinho, Miguel; Sondek, John; Zhang, Qisheng; Mesecar, Andrew D; Liu, Yunlong; Atwood, Brady K; Wyss-Coray, Tony; Nho, Kwangsik; Bissel, Stephanie J; Lamb, Bruce T; Landreth, Gary E.

Immunity ; 56(9): 2121-2136.e6, 2023 09 12.

Artículo Inglés | MEDLINE | ID: mdl-37659412

4.

APOE4/4 is linked to damaging lipid droplets in Alzheimer's disease microglia.

Haney, Michael S; Pálovics, Róbert; Munson, Christy Nicole; Long, Chris; Johansson, Patrik K; Yip, Oscar; Dong, Wentao; Rawat, Eshaan; West, Elizabeth; Schlachetzki, Johannes C M; Tsai, Andy; Guldner, Ian Hunter; Lamichhane, Bhawika S; Smith, Amanda; Schaum, Nicholas; Calcuttawala, Kruti; Shin, Andrew; Wang, Yung-Hua; Wang, Chengzhong; Koutsodendris, Nicole; Serrano, Geidy E; Beach, Thomas G; Reiman, Eric M; Glass, Christopher K; Abu-Remaileh, Monther; Enejder, Annika; Huang, Yadong; Wyss-Coray, Tony.

Nature ; 628(8006): 154-161, 2024 Apr.

Artículo Inglés | MEDLINE | ID: mdl-38480892

5.

Geroscience: linking aging to chronic disease.

Kennedy, Brian K; Berger, Shelley L; Brunet, Anne; Campisi, Judith; Cuervo, Ana Maria; Epel, Elissa S; Franceschi, Claudio; Lithgow, Gordon J; Morimoto, Richard I; Pessin, Jeffrey E; Rando, Thomas A; Richardson, Arlan; Schadt, Eric E; Wyss-Coray, Tony; Sierra, Felipe.

Cell ; 159(4): 709-13, 2014 Nov 06.

Artículo Inglés | MEDLINE | ID: mdl-25417146

6.

Organ aging signatures in the plasma proteome track health and disease.

Oh, Hamilton Se-Hwee; Rutledge, Jarod; Nachun, Daniel; Pálovics, Róbert; Abiose, Olamide; Moran-Losada, Patricia; Channappa, Divya; Urey, Deniz Yagmur; Kim, Kate; Sung, Yun Ju; Wang, Lihua; Timsina, Jigyasha; Western, Dan; Liu, Menghan; Kohlfeld, Pat; Budde, John; Wilson, Edward N; Guen, Yann; Maurer, Taylor M; Haney, Michael; Yang, Andrew C; He, Zihuai; Greicius, Michael D; Andreasson, Katrin I; Sathyan, Sanish; Weiss, Erica F; Milman, Sofiya; Barzilai, Nir; Cruchaga, Carlos; Wagner, Anthony D; Mormino, Elizabeth; Lehallier, Benoit; Henderson, Victor W; Longo, Frank M; Montgomery, Stephen B; Wyss-Coray, Tony.

Nature ; 624(7990): 164-172, 2023 Dec.

Artículo Inglés | MEDLINE | ID: mdl-38057571

7.

An 80,000-Piece Puzzle of Alzheimer's Disease.

Iram, Tal; Keller, Andreas; Wyss-Coray, Tony.

Immunity ; 50(6): 1349-1351, 2019 06 18.

Artículo Inglés | MEDLINE | ID: mdl-31216459

8.

Measuring biological age using omics data.

Rutledge, Jarod; Oh, Hamilton; Wyss-Coray, Tony.

Nat Rev Genet ; 23(12): 715-727, 2022 12.

Artículo Inglés | MEDLINE | ID: mdl-35715611

9.

Molecular hallmarks of heterochronic parabiosis at single-cell resolution.

Pálovics, Róbert; Keller, Andreas; Schaum, Nicholas; Tan, Weilun; Fehlmann, Tobias; Borja, Michael; Kern, Fabian; Bonanno, Liana; Calcuttawala, Kruti; Webber, James; McGeever, Aaron; Luo, Jian; Pisco, Angela Oliveira; Karkanias, Jim; Neff, Norma F; Darmanis, Spyros; Quake, Stephen R; Wyss-Coray, Tony.

Nature ; 603(7900): 309-314, 2022 03.

Artículo Inglés | MEDLINE | ID: mdl-35236985

10.

A human brain vascular atlas reveals diverse mediators of Alzheimer's risk.

Yang, Andrew C; Vest, Ryan T; Kern, Fabian; Lee, Davis P; Agam, Maayan; Maat, Christina A; Losada, Patricia M; Chen, Michelle B; Schaum, Nicholas; Khoury, Nathalie; Toland, Angus; Calcuttawala, Kruti; Shin, Heather; Pálovics, Róbert; Shin, Andrew; Wang, Elizabeth Y; Luo, Jian; Gate, David; Schulz-Schaeffer, Walter J; Chu, Pauline; Siegenthaler, Julie A; McNerney, M Windy; Keller, Andreas; Wyss-Coray, Tony.

Nature ; 603(7903): 885-892, 2022 03.

Artículo Inglés | MEDLINE | ID: mdl-35165441

11.

Young CSF restores oligodendrogenesis and memory in aged mice via Fgf17.

Iram, Tal; Kern, Fabian; Kaur, Achint; Myneni, Saket; Morningstar, Allison R; Shin, Heather; Garcia, Miguel A; Yerra, Lakshmi; Palovics, Robert; Yang, Andrew C; Hahn, Oliver; Lu, Nannan; Shuken, Steven R; Haney, Michael S; Lehallier, Benoit; Iyer, Manasi; Luo, Jian; Zetterberg, Henrik; Keller, Andreas; Zuchero, J Bradley; Wyss-Coray, Tony.

Nature ; 605(7910): 509-515, 2022 05.

Artículo Inglés | MEDLINE | ID: mdl-35545674

12.

Dysregulation of brain and choroid plexus cell types in severe COVID-19.

Yang, Andrew C; Kern, Fabian; Losada, Patricia M; Agam, Maayan R; Maat, Christina A; Schmartz, Georges P; Fehlmann, Tobias; Stein, Julian A; Schaum, Nicholas; Lee, Davis P; Calcuttawala, Kruti; Vest, Ryan T; Berdnik, Daniela; Lu, Nannan; Hahn, Oliver; Gate, David; McNerney, M Windy; Channappa, Divya; Cobos, Inma; Ludwig, Nicole; Schulz-Schaeffer, Walter J; Keller, Andreas; Wyss-Coray, Tony.

Nature ; 595(7868): 565-571, 2021 07.

Artículo Inglés | MEDLINE | ID: mdl-34153974

13.

Exercise plasma boosts memory and dampens brain inflammation via clusterin.

De Miguel, Zurine; Khoury, Nathalie; Betley, Michael J; Lehallier, Benoit; Willoughby, Drew; Olsson, Niclas; Yang, Andrew C; Hahn, Oliver; Lu, Nannan; Vest, Ryan T; Bonanno, Liana N; Yerra, Lakshmi; Zhang, Lichao; Saw, Nay Lui; Fairchild, J Kaci; Lee, Davis; Zhang, Hui; McAlpine, Patrick L; Contrepois, Kévin; Shamloo, Mehrdad; Elias, Joshua E; Rando, Thomas A; Wyss-Coray, Tony.

Nature ; 600(7889): 494-499, 2021 12.

Artículo Inglés | MEDLINE | ID: mdl-34880498

14.

SRF transcriptionally regulates the oligodendrocyte cytoskeleton during CNS myelination.

Iram, Tal; Garcia, Miguel A; Amand, Jérémy; Kaur, Achint; Atkins, Micaiah; Iyer, Manasi; Lam, Mable; Ambiel, Nicholas; Jorgens, Danielle M; Keller, Andreas; Wyss-Coray, Tony; Kern, Fabian; Zuchero, J Bradley.

Proc Natl Acad Sci U S A ; 121(12): e2307250121, 2024 Mar 19.

Artículo Inglés | MEDLINE | ID: mdl-38483990

15.

Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer's disease.

Gate, David; Saligrama, Naresha; Leventhal, Olivia; Yang, Andrew C; Unger, Michael S; Middeldorp, Jinte; Chen, Kelly; Lehallier, Benoit; Channappa, Divya; De Los Santos, Mark B; McBride, Alisha; Pluvinage, John; Elahi, Fanny; Tam, Grace Kyin-Ye; Kim, Yongha; Greicius, Michael; Wagner, Anthony D; Aigner, Ludwig; Galasko, Douglas R; Davis, Mark M; Wyss-Coray, Tony.

Nature ; 577(7790): 399-404, 2020 01.

Artículo Inglés | MEDLINE | ID: mdl-31915375

16.

Physiological blood-brain transport is impaired with age by a shift in transcytosis.

Yang, Andrew C; Stevens, Marc Y; Chen, Michelle B; Lee, Davis P; Stähli, Daniel; Gate, David; Contrepois, Kévin; Chen, Winnie; Iram, Tal; Zhang, Lichao; Vest, Ryan T; Chaney, Aisling; Lehallier, Benoit; Olsson, Niclas; du Bois, Haley; Hsieh, Ryan; Cropper, Haley C; Berdnik, Daniela; Li, Lulin; Wang, Elizabeth Y; Traber, Gavin M; Bertozzi, Carolyn R; Luo, Jian; Snyder, Michael P; Elias, Joshua E; Quake, Stephen R; James, Michelle L; Wyss-Coray, Tony.

Nature ; 583(7816): 425-430, 2020 07.

Artículo Inglés | MEDLINE | ID: mdl-32612231

17.

Ageing hallmarks exhibit organ-specific temporal signatures.

Schaum, Nicholas; Lehallier, Benoit; Hahn, Oliver; Pálovics, Róbert; Hosseinzadeh, Shayan; Lee, Song E; Sit, Rene; Lee, Davis P; Losada, Patricia Morán; Zardeneta, Macy E; Fehlmann, Tobias; Webber, James T; McGeever, Aaron; Calcuttawala, Kruti; Zhang, Hui; Berdnik, Daniela; Mathur, Vidhu; Tan, Weilun; Zee, Alexander; Tan, Michelle; Pisco, Angela Oliveira; Karkanias, Jim; Neff, Norma F; Keller, Andreas; Darmanis, Spyros; Quake, Stephen R; Wyss-Coray, Tony.

Nature ; 583(7817): 596-602, 2020 07.

Artículo Inglés | MEDLINE | ID: mdl-32669715

18.

ZEBRA: a hierarchically integrated gene expression atlas of the murine and human brain at single-cell resolution.

Flotho, Matthias; Amand, Jérémy; Hirsch, Pascal; Grandke, Friederike; Wyss-Coray, Tony; Keller, Andreas; Kern, Fabian.

Nucleic Acids Res ; 52(D1): D1089-D1096, 2024 Jan 05.

Artículo Inglés | MEDLINE | ID: mdl-37941147

19.

Systemic factors as mediators of brain homeostasis, ageing and neurodegeneration.

Pluvinage, John V; Wyss-Coray, Tony.

Nat Rev Neurosci ; 21(2): 93-102, 2020 02.

Artículo Inglés | MEDLINE | ID: mdl-31913356

20.

Author Correction: Systemic factors as mediators of brain homeostasis, ageing and neurodegeneration.